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Registro Completo |
Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
09/01/2020 |
Data da última atualização: |
06/02/2024 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
OTTO, P. I.; GUIMARÃES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; VANDENPLAS, J.; SEVILLANO, C. A.; MARQUES, D. B. D.; PIRES, M. de F. A.; FREITAS, C. de; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GOBO, D. O. R.; SILVA, M. V. G. B.; MACHADO, M. A. |
Afiliação: |
ANA LUISA SOUSA AZEVEDO, CNPGL; MARIA DE FATIMA AVILA PIRES, CNPGL; CELIO DE FREITAS, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARTA FONSECA MARTINS, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MARCO ANTONIO MACHADO, CNPGL. |
Título: |
Genome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
Journal of Dairy Science, v. 102, n. 9, p. 8148-8158, 2019. |
DOI: |
https://doi.org/10.3168/jds.2018-15305 |
Idioma: |
Inglês |
Conteúdo: |
Heat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔRT animals had 2 alleles from the Holstein breed (HH), and 39% had both alleles from the Gir breed (GG). In high-ΔRT animals, the average proportion of animals for HH and GG were 1.4 and 50.2%, respectively. This study allowed the identification of candidate genes for ΔRT in Gir × Holstein crossbred animals. According to the BOA approach, Holstein breed alleles could be associated with better response to heat stress effects, which could be explained by the fact that Holstein animals are more affected by heat stress than Gir animals and thus require a genetic architecture to defend the body from the deleterious effects of heat stress. Future studies can provide further knowledge to uncover the genetic architecture underlying heat stress in crossbred cattle. MenosHeat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔR... Mostrar Tudo |
Palavras-Chave: |
Crossbred cattle; Gene network; Post-GWAS analyses. |
Thesaurus Nal: |
Heat stress. |
Categoria do assunto: |
-- |
Marc: |
LEADER 03369naa a2200361 a 4500 001 2118465 005 2024-02-06 008 2019 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.3168/jds.2018-15305$2DOI 100 1 $aOTTO, P. I. 245 $aGenome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle.$h[electronic resource] 260 $c2019 520 $aHeat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔRT animals had 2 alleles from the Holstein breed (HH), and 39% had both alleles from the Gir breed (GG). In high-ΔRT animals, the average proportion of animals for HH and GG were 1.4 and 50.2%, respectively. This study allowed the identification of candidate genes for ΔRT in Gir × Holstein crossbred animals. According to the BOA approach, Holstein breed alleles could be associated with better response to heat stress effects, which could be explained by the fact that Holstein animals are more affected by heat stress than Gir animals and thus require a genetic architecture to defend the body from the deleterious effects of heat stress. Future studies can provide further knowledge to uncover the genetic architecture underlying heat stress in crossbred cattle. 650 $aHeat stress 653 $aCrossbred cattle 653 $aGene network 653 $aPost-GWAS analyses 700 1 $aGUIMARÃES, S. E. F. 700 1 $aVERARDO, L. L. 700 1 $aAZEVEDO, A. L. S. 700 1 $aVANDENPLAS, J. 700 1 $aSEVILLANO, C. A. 700 1 $aMARQUES, D. B. D. 700 1 $aPIRES, M. de F. A. 700 1 $aFREITAS, C. de 700 1 $aVERNEQUE, R. da S. 700 1 $aMARTINS, M. F. 700 1 $aPANETTO, J. C. do C. 700 1 $aCARVALHO, W. A. 700 1 $aGOBO, D. O. R. 700 1 $aSILVA, M. V. G. B. 700 1 $aMACHADO, M. A. 773 $tJournal of Dairy Science$gv. 102, n. 9, p. 8148-8158, 2019.
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Embrapa Gado de Leite (CNPGL) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria de Alimentos. Para informações adicionais entre em contato com ctaa.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
Data corrente: |
26/01/2011 |
Data da última atualização: |
21/01/2013 |
Tipo da produção científica: |
Comunicado Técnico/Recomendações Técnicas |
Autoria: |
CARVALHO, C. W. P. de; ASCHERI, J. L. R.; TAKEITI, C. Y.; NASCIMENTO, E. M. da G. C. do; FIRMINO, P. de T. |
Afiliação: |
CARLOS WANDERLEI PILER DE CARVALHO, CTAA; JOSE LUIS RAMIREZ ASCHERI, CTAA; CRISTINA YOSHIE TAKEITI, CTAA; ELISABETE MARIA DA GRAÇA COSTA DO NASCIMENTO, UFRRJ; PAULO DE TARSO FIRMINO, CNPA. |
Título: |
Elaboração de farinha instantânea de milho e de gergelim integral por extrusão. |
Ano de publicação: |
2010 |
Fonte/Imprenta: |
Rio de Janeiro: Embrapa Agroindústria de Alimentos, 2010. |
Série: |
(Embrapa Agroindústria de Alimentos. Comunicado técnico, 168). |
Idioma: |
Português |
Palavras-Chave: |
Farinha instantânea; Semente de gergelim. |
Thesagro: |
Extrusão; Milho. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 00681nam a2200205 a 4500 001 1874463 005 2013-01-21 008 2010 bl uuuu u0uu1 u #d 100 1 $aCARVALHO, C. W. P. de 245 $aElaboração de farinha instantânea de milho e de gergelim integral por extrusão. 260 $aRio de Janeiro: Embrapa Agroindústria de Alimentos$c2010 490 $a(Embrapa Agroindústria de Alimentos. Comunicado técnico, 168). 650 $aExtrusão 650 $aMilho 653 $aFarinha instantânea 653 $aSemente de gergelim 700 1 $aASCHERI, J. L. R. 700 1 $aTAKEITI, C. Y. 700 1 $aNASCIMENTO, E. M. da G. C. do 700 1 $aFIRMINO, P. de T.
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